Article
A human fungal pathogen Cryptococcus neoformans expresses three distinct iron permease homologs.
Journal of microbiology and biotechnology - 1 Dec 2012
Han Kyunghwan, Do Eunsoo, Jung Won Hee
Abstract excerpt
Iron plays a key role in host-pathogen interactions. Microbial pathogens require iron for survival and virulence, whereas mammalian hosts sequester and withhold iron as a means of nutritional immunity. We previously identified two paralogous genes, CFT1 and CFT2, which encode homologs of a fungal iron permease, Cft1 and Cft2, respectively, in the human fungal pathogen Cryptococcus neoformans. Cft1 was shown to...
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