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Article

Disproportional effects of <i>Igf2</i> knockout on placental morphology and diffusional exchange characteristics in the mouse

14 Oct 2008

Abstract excerpt

Both complete knockout of the Igf2 gene (Igf2null(+/-)) and knockout of its placental specific transcript alone (Igf2P0(+/-)) lead to fetal growth restriction in mice. However, in the Igf2null(+/-) this growth restriction occurs concurrently in gestation with placental growth restriction, whereas, placental growth restriction precedes fetal growth restriction in the Igf2P0(+/-) mouse. Previous studies have shown...

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PMID: 18755750
DOI: 10.1113/jphysiol.2008.157313

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