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Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases

28 Apr 2019

Abstract excerpt

Modulation of telomerase maintenance by gene therapy must meet two polarizing requirements to achieve different therapeutic outcomes: Anti-aging/regenerative applications require upregulation, while anticancer applications necessitate suppression of various genes integral to telomere maintenance (e.g., telomerase, telomerase RNA components, and shelterin complex). Patients suffering from aging-associated...

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Share to Telomeres, Telomerase, and Senescence
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PMID: 31035374
DOI: 10.3390/cells8050392

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