Article
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
5 Nov 2020
Abstract excerpt
expression in human HCV entry factor transgenic mice increased hepatocyte permissiveness for an adapted HCV strain and dysregulated expression of metabolic process and host defense genes. These findings highlight human-mouse differences in liver-intrinsic antiviral immunity and facilitate the development of next-generation murine models for preclinical testing of HCV vaccine candidates.
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