Article
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
Gut - 1 Jul 2013
Shi Niu, Hiraga Nobuhiko, Imamura Michio, Hayes C Nelson, Zhang Yizhou, Kosaka Keiichi, Okazaki Akihito, Murakami Eisuke, Tsuge Masataka, Abe Hiromi, Aikata Hiroshi, Takahashi Shoichi, Ochi Hidenori, Tateno-Mukaidani Chise, Yoshizato Katsutoshi, Matsui Hirotaka, Kanai Akinori, Inaba Toshiya, McPhee Fiona, Gao Min, Chayama Kazuaki
Abstract excerpt
OBJECTIVE: We recently demonstrated that combination treatment with NS3 protease and NS5B polymerase inhibitors succeeded in eradicating the virus in genotype 1b hepatitis C virus (HCV)-infected mice. In this study, we investigated the effect of combining an NS5A replication complex inhibitor (RCI) with either NS3 protease or NS5B inhibitors on elimination of HCV genotypes 1b, 2a and 2b. DESIGN: The effects of...
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