Arrestin mRNA expression, biosynthesis, and localization in degenerating photoreceptors of mutant rds mice retinas.

Abstract excerpt

The retinal photoreceptors of the mutant rds mouse are unable to form normal outer segments. Eventually the abnormal cells die in the months following birth. The genetic defect in the rds mouse was recently localized to the peripherin gene that encodes a protein in the outer segment disc margin. Although this mutation may explain the morphogenetic defect, i.e., the failure to form outer segments, the reason for...

Topics

• Animals
• Antigens
• Arrestin
• Blotting, Northern
• Eye Proteins
• Gene Expression
• Immunohistochemistry
• Mice
• Mice, Inbred BALB C
• Mice, Mutant Strains
• Mutation
• Photoreceptor Cells