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Article

Modulating Expression of Peripherin/<i>rds</i>in Transgenic Mice: Critical Levels and the Effect of Overexpression

26 Jul 2004

Abstract excerpt

PURPOSE: Mutations in the photoreceptor-specific protein peripherin/rds are associated with multiple retinal diseases. To date, attempts to achieve complete structural and functional rescue in animal models of peripherin/rds-induced retinal degeneration have not been successful. Gene therapy-directed approaches have been hindered by the haploinsufficiency phenotype, which dictates well-regulated expression of...

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PMID: 15277471
DOI: 10.1167/iovs.04-0065

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulating Expression of Peripherin/<i>rds</i>in Transgenic Mice: Critical Levels and the Effect of OverexpressionPMID 15277471Read ↗

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