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Article

Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors.

Investigative ophthalmology & visual science - 1 Feb 1997

Kedzierski W, Lloyd M, Birch D G, Bok D, Travis G H

Abstract excerpt

PURPOSE: In this study, the authors present the biochemical, morphologic, and physiological analyses of a transgenic mouse model for retinal degeneration slow (RDS)-mediated retinitis pigmentosa caused by a proline 216 to leucine (P216L) amino acid substitution in rds/peripherin. METHODS: The authors assembled a mutant rds transgene that encodes rds/peripherin with a P216L substitution. Transgenic mice were...

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PMID: 9040483

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Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors.PMID 9040483Read ↗

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