Article
Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors.
Investigative ophthalmology & visual science - 1 Feb 1997
Kedzierski W, Lloyd M, Birch D G, Bok D, Travis G H
Abstract excerpt
PURPOSE: In this study, the authors present the biochemical, morphologic, and physiological analyses of a transgenic mouse model for retinal degeneration slow (RDS)-mediated retinitis pigmentosa caused by a proline 216 to leucine (P216L) amino acid substitution in rds/peripherin. METHODS: The aut...
Topics
- Animals
- DNA Primers
- Disease Models, Animal
- Electroretinography
- Eye Proteins
- Gene Expression
- Intermediate Filament Proteins
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mice, Transgenic
- Microscopy, Immunoelectron
- Nerve Tissue Proteins
- Peripherins
- Phenotype
- Retinal Degeneration
- Retinal Rod Photoreceptor Cells