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Article

A polygenic model with common variants may predict lung adenocarcinoma risk in humans.

International journal of cancer - 15 Nov 2008

Galvan Antonella, Falvella Felicia S, Spinola Monica, Frullanti Elisa, Leoni Vera P, Noci Sara, Alonso Maria R, Zolin Anna, Spada Elena, Milani Silvano, Pastorino Ugo, Incarbone Matteo, Santambrogio Luigi, Gonzalez Neira Anna, Dragani Tommaso A

Abstract excerpt

Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic...

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Identifiers

PMID: 18729187
DOI: 10.1002/ijc.23789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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