Article
Cytochrome P450 2J2*7 polymorphisms in Japanese, Mongolians and Ovambos.
Cell biochemistry and function - 1 Oct 2008
Takeshita Haruo, Tsubota Etsuko, Takatsuka Hisakazu, Kunito Takashi, Fujihara Junko
Abstract excerpt
Human cytochrome P450 2J2 (CYP2J2) is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that have potent vasodilatory properties. Variability of the CYP2J2 gene is highly constrained except for its proximal promoter: there is a relatively common and functionally relevant single nucleotide polymorphism, indicated by -50G > T polymorphism (CYP2J2*7). Although genetic...
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