Article
Strial microvascular pathology and age-associated endocochlear potential decline in NOD congenic mice.
Hearing research - 1 Oct 2008
Ohlemiller Kevin K, Rice Mary E Rybak, Gagnon Patricia M
Abstract excerpt
NOD/ShiLtJ (previously NOD/LtJ) inbred mice show polygenic autoimmune disease and are commonly used to model autoimmune-related type I diabetes, as well as Sjogren's syndrome. They also show rapidly progressing hearing loss, partly due to the combined effects of Cdh23ahl and Ahl2. Congenic NOD.NON-H2nb1/LtJ mice, which carry corrective alleles within the H2 histocompatibility gene complex, are free from diabetes...
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