Article

Development of a major histocompatibility complex class II conditional knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves

2023-07-26

Abstract excerpt

<h4>Introduction</h4> Major histocompatibility complex (MHC) class II professional antigen presenting cell-naïve CD4+ T cell interactions via the T-cell receptor complex are necessary for adaptive immunity. MHC class II upregulation in multiple cell types occurs in human autoimmune polyneuropathy patient biopsies, necessitating studies to ascertain cellular signaling pathways required for tissue-specific autoimmu...

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Literature Corpus work: 018ce045-3497-5651-9c69-92e7d469f1a5
DOI: 10.1101/2023.07.24.550421

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