Article
Association of the variants in AGT gene with modified drug response in Korean aspirin-intolerant asthma patients.
Pulmonary pharmacology & therapeutics - 1 Oct 2011
Pasaje Charisse Flerida A, Kim Jeong-Hyun, Park Byung-Lae, Cheong Hyun Sub, Park Tae-Joon, Lee Jin-Sol, Kim Yongha, Bae Joon Seol, Kim Jin Moo, Park Jong Sook, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
The angiotensinogen (AGT) gene enhances the effect of several bronchoconstrictors and produces a peptide that is accumulated in the airways of asthma patients; events that may underpin the pathogenesis of aspirin-intolerant asthma (AIA). To carry out a case-control analysis between AGT and aspirin-induced bronchospasm following treatment with an anti-asthma drug, montelukast (MLK), 38 single nucleotide...
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