Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.

The Journal of experimental medicine - 1 Sept 2008

Zhou Xuyu, Jeker Lukas T, Fife Brian T, Zhu Shirley, Anderson Mark S, McManus Michael T, Bluestone Jeffrey A

Abstract excerpt

A new regulatory T (T reg) cell-specific, FoxP3-GFP-hCre bacterial artificial chromosome transgenic mouse was crossed to a conditional Dicer knockout (KO) mouse strain to analyze the role of microRNAs (miRNAs) in the development and function of T reg cells. Although thymic T reg cells developed normally in this setting, the cells showed evidence of altered differentiation and dysfunction in the periphery....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Artificial, Bacterial

Share to DEAD-box RNA Helicases

Share to Endoribonucleases

Share to Immune System

Share to Ribonuclease III

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 18725525
DOI: 10.1084/jem.20080707
PMCID: PMC2526194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.PMID 18725525Read ↗

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.Semantic proximity Read ↗

Selective ablation of thymic and peripheral Foxp3 <sup>+</sup> regulatory T cell developmentSemantic proximity Read ↗

Dicer Insufficiency and MicroRNA-155 Overexpression in Lupus Regulatory T Cells: An Apparent Paradox in the Setting of an Inflammatory MilieuSemantic proximity Read ↗

Regulatory T cells in human autoimmune diseases.Semantic proximity Read ↗

Identification and characterization of T reg-like cells in zebrafish.Semantic proximity Read ↗

Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice.Semantic proximity Read ↗

Transgenic Expression of a Mutant Ribonuclease Regnase-1 in T Cells Disturbs T Cell Development and Functions.Semantic proximity Read ↗

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host DiseaseSemantic proximity Read ↗

CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.Semantic proximity Read ↗

Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunitySemantic proximity Read ↗

Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.Semantic proximity Read ↗

Genetic Variations Controlling Regulatory T Cell Development and Activity in Mouse Models of Lupus-Like Autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.