Article
Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein.
Genetics - 1 Sept 2008
Pinto Belinda S, Wilmington Shameika R, Hornick Emma E L, Wallrath Lori L, Geyer Pamela K
Abstract excerpt
The nuclear lamina represents a protein network required for nuclear structure and function. One family of lamina proteins is defined by an approximately 40-aa LAP2, Emerin, and MAN1 (LEM) domain (LEM-D) that binds the nonspecific DNA-binding protein, barrier-to-autointegration factor (BAF). Through interactions with BAF, LEM-D proteins serve as a bridge between chromosomes and the nuclear envelope. Mutations in...
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