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Article

Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.

The Journal of cell biology - 5 Aug 2002

Segura-Totten Miriam, Kowalski Amy K, Craigie Robert, Wilson Katherine L

Abstract excerpt

Barrier-to-autointegration factor (BAF) is a DNA-bridging protein, highly conserved in metazoans. BAF binds directly to LEM (LAP2, emerin, MAN1) domain nuclear membrane proteins, including LAP2 and emerin. We used site-directed mutagenesis and biochemical analysis to map functionally important residues in human BAF, including those required for direct binding to DNA or emerin. We also tested wild-type BAF and 25...

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Share to Chromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12163470
DOI: 10.1083/jcb.200202019
PMCID: PMC2173821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.PMID 12163470Read ↗

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