Article
Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray.
Experimental hematology - 1 Nov 2008
Kawamata Norihiko, Ogawa Seishi, Yamamoto Go, Lehmann Soren, Levine Ross L, Pikman Yana, Nannya Yasuhito, Sanada Masashi, Miller Carl W, Gilliland D Gary, Koeffler H Phillip
Abstract excerpt
OBJECTIVE: Myeloproliferative disorders (MPD) are clonal hematopoietic diseases that include polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF). Mutations in JAK2 are present in many MPD patients. Additional genomic abnormalities are not fully examined in MPD. MATERIALS AND METHODS: We used single-nucleotide polymorphism DNA microarray (SNP-chip) to analyze 43 patients with MPD...
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