Article
High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations.
Haematologica - 1 Apr 2010
Stegelmann Frank, Bullinger Lars, Griesshammer Martin, Holzmann Karlheinz, Habdank Marianne, Kuhn Susanne, Maile Carmen, Schauer Stefanie, Döhner Hartmut, Döhner Konstanze
Abstract excerpt
Single-nucleotide polymorphism arrays allow for genome-wide profiling of copy-number alterations and copy-neutral runs of homozygosity at high resolution. To identify novel genetic lesions in myeloproliferative neoplasms, a large series of 151 clinically well characterized patients was analyzed in our study. Copy-number alterations were rare in essential thrombocythemia and polycythemia vera. In contrast,...
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