Article
Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomy.
Experimental hematology - 1 Feb 2009
Nowak Daniel, Nolte Florian, Mossner Maximilian, Nowak Verena, Baldus Claudia D, Hopfer Olaf, Noll Stefanie, Thiel Eckhard, Wagner Florian, Hofmann Wolf-Karsten
Abstract excerpt
OBJECTIVE: Identification of genomic lesions in progenitor cells of patients with myelodysplastic syndrome (MDS) could lead to the discovery of new disease-specific genes and may be of prognostic value. MATERIALS AND METHODS: We carried out a genome-wide mapping of DNA from CD34+ cells of MDS patients with high-resolution 500K single nucleotide polymorphism arrays and a concomitant integration with global gene...
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