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Article

Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes

16 Sept 2003

Abstract excerpt

OBJECTIVES: The sarcoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) is essential to the removal of cytosolic calcium following cardiac contraction, and its abundance and activity are significantly altered during perinatal development and in failing myocardium. The objective of the current study was to identify cis regulatory elements and nuclear transcription factors responsible for transactivating SERCA2 gene...

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PMID: 14613864
DOI: 10.1016/s0008-6363(03)00529-7

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