Functional analysis of the mouse ICER (Inducible cAMP Early Repressor) promoter: evidence for a protein that blocks calcium responsiveness of the CAREs (cAMP autoregulatory elements).

doi:10.1210/mend.13.7.0319

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Article

Functional analysis of the mouse ICER (Inducible cAMP Early Repressor) promoter: evidence for a protein that blocks calcium responsiveness of the CAREs (cAMP autoregulatory elements).

Molecular endocrinology (Baltimore, Md.) - 1 Jul 1999

Krueger D A, Mao D, Warner E A, Dowd D R

Abstract excerpt

Although Ca2+ and cAMP mediate their effects through distinct pathways, both signals converge upon the phosphorylation of the cAMP response element (CRE) binding protein, CREB, thereby activating transcription of CRE-regulated genes. In WEHI7.2 thymocytes, cAMP increases the expression of the inducible cAMP early repressor (ICER) gene through CRE-like elements, known as cAMP autoregulatory elements (CAREs)....

Topics

Animals
Base Sequence
Binding Sites
Calcium
Cells, Cultured
Cyclic AMP
Cyclic AMP Response Element Modulator
DNA-Binding Proteins
Humans
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Promoter Regions, Genetic

Proteins

Repressor Proteins

Response Elements

Thymus Gland

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 10406470
DOI: 10.1210/mend.13.7.0319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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