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Article

Role of cAMP Response Element Binding Protein in Cardiovascular Remodeling

18 Nov 2005

Abstract excerpt

The cAMP response element binding protein (CREB) is a ubiquitously expressed nuclear transcription factor that is activated by various extracellular stimuli. CREB is known to regulate the expression of genes important to cell proliferation, differentiation, adaptation, and survival in many cell types. Loss of CREB function by transgenic overexpression of dominant negative CREB or targeted deletion of the CREB...

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PMID: 16293792
DOI: 10.1161/01.atv.0000196747.79349.d1

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