Article
Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.
Human biology - 1 Apr 2008
Aberg Karolina, Sun Guangyun, Smelser Diane, Indugula Subba Rao, Tsai Hui-Ju, Steele Matthew S, Tuitele John, Deka Ranjan, McGarvey Stephen T, Weeks Daniel E
Abstract excerpt
Type 2 diabetes mellitus (T2DM) is a common complex phenotype that by the year 2010 is predicted to affect 221 million people globally. In the present study we performed a genome-wide linkage scan using the allele-sharing statistic Sall implemented in Allegro and a novel two-dimensional genome-wide strategy implemented in Merloc that searches for pairwise interaction between genetic markers located on different...
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