Article
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height.
American journal of human genetics - 1 Jul 2001
Hirschhorn J N, Lindgren C M, Daly M J, Kirby A, Schaffner S F, Burtt N P, Altshuler D, Parker A, Rioux J D, Platko J, Gaudet D, Hudson T J, Groop L C, Lander E S
Abstract excerpt
Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common human diseases and other complex traits in which multiple genetic and environmental factors interact to influence disease risk. We hypothesized that a highly heritable complex trait, in which the contribution of...
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