Molecular mechanism of estrogen action in the male: insights from the estrogen receptor null mice

Abstract excerpt

Until recently, 17beta-estradiol was thought to be of little importance in male fertility. However, the descriptions of testicular dysfunction and behavioral deficits leading to complete infertility in male mice lacking estrogen receptor alpha (ERalpha) have indicated the importance of estrogen action in fertility of the male rodent. In contrast, male mice lacking the newly discovered estrogen receptor beta...

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