Article
Genetic subspecies diversity of the chimpanzee CD4 virus-receptor gene.
Genomics - 1 Nov 2008
Hvilsom Christina, Carlsen Frands, Siegismund Hans R, Corbet Sylvie, Nerrienet Eric, Fomsgaard Anders
Abstract excerpt
Chimpanzees are naturally and asymptomatically infected by simian immunodeficiency virus (SIV). Pathogenic properties of SIV/HIV vary and differences in susceptibility and pathogenicity of SIV/HIV depend in part on host-specific factors such as virus-receptor/co-receptor interactions. Since CD4 plays a primary role in virus binding and since SIVcpz have been found only in two African chimpanzee subspecies, we...
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