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Article

The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2008

Samani Nilesh J, Braund Peter S, Erdmann Jeanette, Götz Anika, Tomaszewski Maciej, Linsel-Nitschke Patrick, Hajat Cother, Mangino Massimo, Hengstenberg Christian, Stark Klaus, Ziegler Andreas, Caulfield Mark, Burton Paul R, Schunkert Heribert, Tobin Martin D

Abstract excerpt

Through genome-wide association studies, we have recently identified seven novel loci that confer a substantial increase in risk for coronary artery disease (CAD). Elucidating the mechanisms by which these loci affect CAD risk could have important clinical utility. Here, we investigated whether these loci act through mechanisms involving traditional cardiovascular risk factors. We genotyped 2,037 adult...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18649068
DOI: 10.1007/s00109-008-0387-2

Genes

CAD
CELSR2
PSRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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