Article
A high-density SNP panel reveals extensive diversity, frequent recombination and multiple recombination hotspots within the chicken major histocompatibility complex B region between BG2 and CD1A1.
Genetics, selection, evolution : GSE - 7 Jan 2016
Fulton Janet E, McCarron Amy M, Lund Ashlee R, Pinegar Kara N, Wolc Anna, Chazara Olympe, Bed'Hom Bertrand, Berres Mark, Miller Marcia M
Abstract excerpt
BACKGROUND: The major histocompatibility complex (MHC) is present within the genomes of all jawed vertebrates. MHC genes are especially important in regulating immune responses, but even after over 80 years of research on the MHC, much remains to be learned about how it influences adaptive and innate immune responses. In most species, the MHC is highly polymorphic and polygenic. Strong and highly reproducible...
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