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Article

Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Dec 1993

Schmitt M E, Clayton D A

Abstract excerpt

RNase MRP is a site-specific ribonucleoprotein endoribonuclease that cleaves RNA from the mitochondrial origin of replication in a manner consistent with a role in priming leading-strand DNA synthesis. Despite the fact that the only known RNA substrate for this enzyme is complementary to mitochondrial DNA, the majority of the RNase MRP activity in a cell is found in the nucleus. The recent characterization of...

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Identifiers

PMID: 8247008
DOI: 10.1128/mcb.13.12.7935-7941.1993
PMCID: PMC364865

Genes

NME1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae.PMID 8247008Read ↗

Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes.Semantic proximity Read ↗

The RNA of RNase MRP is required for normal processing of ribosomal RNA.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

Identification of a functional core in the RNA component of RNase MRP of budding yeasts.Semantic proximity Read ↗

Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages.Semantic proximity Read ↗

RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway.Semantic proximity Read ↗

Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs.Semantic proximity Read ↗

Global identification of new substrates for the yeast endoribonuclease, RNase mitochondrial RNA processing (MRP).Semantic proximity Read ↗

rRNA maturation in yeast cells depleted of large ribosomal subunit proteins.Semantic proximity Read ↗

An RNase P RNA subunit mutation affects ribosomal RNA processing.Semantic proximity Read ↗

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.Semantic proximity Read ↗

The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins.Semantic proximity Read ↗

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