Article
Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.
RNA (New York, N.Y.) - 1 Jun 2006
Xiao Shaohua, Hsieh John, Nugent Rebecca L, Coughlin Daniel J, Fierke Carol A, Engelke David R
Abstract excerpt
RNase P and RNase MRP are ribonucleoprotein enzymes required for 5'-end maturation of precursor tRNAs (pre-tRNAs) and processing of precursor ribosomal RNAs, respectively. In yeast, RNase P and MRP holoenzymes have eight protein subunits in common, with Pop1p being the largest at >100 kDa. Little is known about the functions of Pop1p, beyond the fact that it binds specifically to the RNase P RNA subunit, RPR1...
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