Article
Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008
Ellekvist Peter, Maciel Jorge, Mlambo Godfree, Ricke Christina H, Colding Hanne, Klaerke Dan A, Kumar Nirbhay
Abstract excerpt
Regulated K(+) transport across the plasma membrane is of vital importance for the survival of most cells. Two K(+) channels have been identified in the Plasmodium falciparum genome; however, their functional significance during parasite life cycle in the vertebrate host and during transmission through the mosquito vector remains unknown. We hypothesize that these two K(+) channels mediate the transport of K(+)...
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