Article
Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.
Immunology - 1 Dec 2002
Mack David L, Leibowitz David S, Cooper Scott, Ramsey Heather, Broxmeyer Hal E, Hromas Robert
Abstract excerpt
The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in T cells (CD11a/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation,...
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