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Article

Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.

Immunology - 1 Dec 2002

Mack David L, Leibowitz David S, Cooper Scott, Ramsey Heather, Broxmeyer Hal E, Hromas Robert

Abstract excerpt

The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12460189
DOI: 10.1046/j.1365-2567.2002.01523.x
PMCID: PMC1782816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12460189-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.PMID 12460189Read ↗

Identification and characterization of the hematopoietic cell-specific enhancer-like element of the mouse hex gene.Semantic proximity Read ↗

Genomic organization and promoter analysis of a mouse homeobox gene, Hex.Semantic proximity Read ↗

Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.Semantic proximity Read ↗

Identification of the transactivating region of the homeodomain protein, hex.Semantic proximity Read ↗

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors.Semantic proximity Read ↗

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.Semantic proximity Read ↗

Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish.Semantic proximity Read ↗

pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus.Semantic proximity Read ↗

Sex-, stage- and tissue-specific regulation by a mosquito hexamerin promoter.Semantic proximity Read ↗

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