Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple mutations conferring ciprofloxacin resistance in Staphylococcus aureus demonstrate long-term stability in an antibiotic-free environment.

The Journal of antimicrobial chemotherapy - 1 Mar 2000

Jones M E, Boenink N M, Verhoef J, Köhrer K, Schmitz F J

Abstract excerpt

Two unrelated strains of Staphylococcus aureus, one with a single mutation in grlA, the other with multiple mutations in gyrA, gyrB, grlA, grlB, norA and the norA promoter region, encoding low-level and high-level ciprofloxacin resistance, respectively, were studied. The characterized mutations in these genes were conserved when both strains were passaged for at least 500 generations in an antibiotic-free...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Ciprofloxacin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Genotype

Share to Microbial Sensitivity Tests

Share to Point Mutation

Share to Promoter Regions, Genetic

Share to Staphylococcus aureus

Source

Identifiers

PMID: 10702556
DOI: 10.1093/jac/45.3.353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple mutations conferring ciprofloxacin resistance in Staphylococcus aureus demonstrate long-term stability in an antibiotic-free environment.PMID 10702556Read ↗

Phenotype and genotype alteration during adaptive evolution of Enterococcus faecalis to antimicrobials.Semantic proximity Read ↗

Effects of low-level ciprofloxacin challenge in the in vitro development of ciprofloxacin resistance in Campylobacter jejuni.Semantic proximity Read ↗

Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa.Semantic proximity Read ↗

Comparative genome analysis of ciprofloxacin-resistant Pseudomonas aeruginosa reveals genes within newly identified high variability regions associated with drug resistance development.Semantic proximity Read ↗

Exploring antibiotic-induced persister formation and bacterial persistence genes in clinical isolates from Burkina FasoSemantic proximity Read ↗

Role of antibiotic stress in phenotypic switching to persister cells of antibiotic-resistant Staphylococcus aureusSemantic proximity Read ↗

Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.Semantic proximity Read ↗

Ciprofloxacin-induced, low-level resistance to structurally unrelated antibiotics in Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus.Semantic proximity Read ↗

Extended spectrum of quinolone resistance, even to a potential latter third-generation agent, as a result of a minimum of two GrlA and two GyrA alterations in quinolone-resistant Staphylococcus aureus.Semantic proximity Read ↗

Novel ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus.Semantic proximity Read ↗

Staphylococcus aureus mutants isolated via exposure to nonfluorinated quinolones: detection of known and unique mutations.Semantic proximity Read ↗

Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.