Enhanced <i>in vivo</i> fitness of fluoroquinolone-resistant <i>Campylobacter jejuni</i> in the absence of antibiotic selection pressure

Abstract excerpt

Campylobacter jejuni, a major foodborne human pathogen, has become increasingly resistant to fluoroquinolone (FQ) antimicrobials. By using clonally related isolates and genetically defined mutants, we determined the fitness of FQ-resistant Campylobacter in chicken (a natural host and a major reservoir for C. jejuni) in the absence of antibiotic selection pressure. When monoinoculated into the host, FQ-resistant...