Article
The histopathology of a human mesenchymal stem cell experimental tumor model: support for an hMSC origin for Ewing's sarcoma?
Histology and histopathology - 1 Oct 2008
Burns J S, Abdallah B M, Schrøder H D, Kassem M
Abstract excerpt
Sarcomas display varied degrees of karyotypic abnormality, vascularity and mesenchymal differentiation. We have reported that a strain of telomerized adult human bone marrow mesenchymal stem cells (hMSC-TERT20) spontaneously evolved a tumorigenic phenotype after long-term continuous culture. We asked to what extent our hMSC-TERT20 derived tumors reflected events found in human sarcomas using routine...
Topics
- Actins
- Animals
- Biomarkers, Tumor
- Bone Neoplasms
- Cell Cycle Proteins
- Cell Differentiation
- Cell Line, Tumor
- Cell Lineage
- Cell Proliferation
- Cell Transformation, Neoplastic
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry