Article
Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2008
Yang Jin, Kamide Kei, Kokubo Yoshihiro, Takiuchi Shin, Horio Takeshi, Matayoshi Tetsutaro, Yasuda Hisayo, Miwa Yoshikazu, Yoshii Masayoshi, Yoshihara Fumiki, Nakamura Satoko, Nakahama Hajime, Tomoike Hitonobu, Miyata Toshiyuki, Kawano Yuhei
Abstract excerpt
Hyperuricemia and oxidative stress participate in the pathophysiology of hypertension and its complications. Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species. Here we have studied whether or not the genetic variations in XDH could be implicated in hypertension and its complications. By sequencing the promoter region and all exons of XDH in 48 subjects, we identified...
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