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Exploring the relationship between XDH gene variants and serum urate and xanthine dehydrogenase levels in gout.

Clinical rheumatology - 1 Apr 2026

Román-Olmos Juan Alan, Zamudio-Cuevas Yessica, Martínez-Flores Karina, Espinosa-Morales Rolando, Fernández-Torres Javier

Abstract excerpt

BACKGROUND: Gout is a type of arthritis caused by high levels of urate in the body, leading to inflammation and joint pain. Xanthine dehydrogenase (XDH) is a key enzyme in urate biosynthesis, and genetic variations in its XDH gene can influence the amount or activity of the enzyme, as well as the levels of urate produced. OBJECTIVES: This study aimed to explore the association of two single nucleotide variants...

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Identifiers

PMID: 41729472
DOI: 10.1007/s10067-026-08002-4

Genes

XDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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