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Article

Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study.

Journal of hypertension - 1 Nov 2016

Scheepers Lieke E J M, Wei Fang-Fei, Stolarz-Skrzypek Katarzyna, Malyutina Sofia, Tikhonoff Valérie, Thijs Lutgarde, Salvi Erika, Barlassina Cristina, Filipovský Jan, Casiglia Edoardo, Nikitin Yuri, Kawecka-Jaszcz Kalina, Manunta Paolo, Cusi Daniele, Boonen Annelies, Staessen Jan A, Arts Ilja C W

Abstract excerpt

OBJECTIVE: The enzyme xanthine oxidoreductase (XOR) generates uric acid in the terminal steps of the purine metabolism; meanwhile reactive oxygen species are formed. We hypothesized that uric acid production, as assessed indirectly from XOR variants, is associated with hypertension. METHODS: Among 2769 participants (48.3% men; mean age 40.7 years) randomly recruited from European populations, we genotyped 25...

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PMID: 27607461
DOI: 10.1097/HJH.0000000000001077

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