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Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied

18 Aug 2008

Abstract excerpt

When the spindle assembly checkpoint (SAC) cannot be satisfied, cells exit mitosis via mitotic slippage. In microtubule (MT) poisons, slippage requires cyclin B proteolysis, and it appears to be accelerated in drug concentrations that allow some MT assembly. To determine if MTs accelerate slippage, we followed mitosis in human RPE-1 cells exposed to various spindle poisons. At 37 degrees C, the duration of...

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PMID: 18710927
DOI: 10.1083/jcb.200805072

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