Article
The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE‐1) and cancer (U2OS, HeLa) cells
12 Sept 2008
Abstract excerpt
We used live cell imaging to compare the fate of human nontransformed (RPE-1) and cancer (HeLa, U2OS) cells as they entered mitosis in nocodazole or taxol. In the same field, and in either drug, a cell in all lines could die in mitosis, exit mitosis and die within 10 h, or exit mitosis and survive > or =10 h. Relative to RPE-1 cells, significantly fewer HeLa or U2OS cells survived mitosis or remained viable after...
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