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Article

Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes.

Genes & development - 15 Aug 2008

Haeusler Rebecca A, Pratt-Hyatt Matthew, Good Paul D, Gipson Theresa A, Engelke David R

Abstract excerpt

The 274 tRNA genes in Saccharomyces cerevisiae are scattered throughout the linear maps of the 16 chromosomes, but the genes are clustered at the nucleolus when compacted in the nucleus. This clustering is dependent on intact nucleolar organization and contributes to tRNA gene-mediated (tgm) silencing of RNA polymerase II transcription near tRNA genes. After examination of the localization mechanism, we find that...

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Identifiers

PMID: 18708579
DOI: 10.1101/gad.1675908
PMCID: PMC2518813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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