Article
Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.) - 1 Oct 2008
Vyshkina Tamara, Sylvester Andrew, Sadiq Saud, Bonilla Eduardo, Canter Jeff A, Perl Andras, Kalman Bernadette
Abstract excerpt
Mitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). This study re-investigates the roles of previously suggested candidate genes of energy metabolism (Complex I genes located in the nucleus and in the mitochondria) in patients with MS relative to ethnically matched SLE patients and healthy controls. After stringent correction for...
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