Article
DAT genotype modulates brain and behavioral responses elicited by cigarette cues.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2009
Franklin Teresa R, Lohoff Falk W, Wang Ze, Sciortino Nathan, Harper Derek, Li Yin, Jens Will, Cruz Jeffrey, Kampman Kyle, Ehrman Ron, Berrettini Wade, Detre John A, O'Brien Charles P, Childress Anna Rose
Abstract excerpt
We previously demonstrated differential activation of the mesocorticolimbic reward circuitry in response to cigarette cues independent of withdrawal. Despite robust effects, we noted considerable individual variability in brain and subjective responses. As dopamine (DA) is critical for reward and its predictive signals, genetically driven variation in DA transmission may account for the observed differences....
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