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Article

Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.

Brain : a journal of neurology - 1 Jul 2020

Vardar Gülçin, Gerth Fabian, Schmitt Xiao Jakob, Rautenstrauch Pia, Trimbuch Thorsten, Schubert Julian, Lerche Holger, Rosenmund Christian, Freund Christian

Abstract excerpt

Syntaxin 1B (STX1B) is a core component of the N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex that is critical for the exocytosis of synaptic vesicles in the presynapse. SNARE-mediated vesicle fusion is assisted by Munc18-1, which recruits STX1B in the auto-inhibited conformation, while Munc13 catalyses the fast and efficient pairing of helices during SNARE complex formation....

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Identifiers

PMID: 32572454
DOI: 10.1093/brain/awaa151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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