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Article

Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo.

The Journal of biological chemistry - 31 Oct 2008

Hunt James, Bracher Marguerite G, Shi Jianguo, Fleury Sébastien, Dombrowicz David, Gould Hannah J, Sutton Brian J, Beavil Andrew J

Abstract excerpt

The high affinity of IgE for its receptor, FcepsilonRI (K(a) approximately 10(10) M(-1)), is responsible for the persistence of mast cell sensitization. Cross-linking of FcepsilonRI-bound IgE by multivalent allergen leads to cellular activation and release of pro-inflammatory mediators responsible for the symptoms of allergic disease. We previously demonstrated that limiting the IgE-FcepsilonRI interaction to...

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Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

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Share to Immunoglobulin E

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Share to Receptors, IgE

Source

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Identifiers

PMID: 18703499
DOI: 10.1074/jbc.M804742200
PMCID: PMC2662060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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