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Article

Modifications to an Fcgamma-Fcvarepsilon fusion protein alter its effectiveness in the inhibition of FcvarepsilonRI-mediated functions.

The Journal of allergy and clinical immunology - 1 Aug 2007

Allen Lisa Chan, Kepley Christopher L, Saxon Andrew, Zhang Ke

Abstract excerpt

BACKGROUND: GE2, a human bifunctional Fcgamma-Fcvarepsilon fusion protein cross-links FcgammaRIIb and FcvarepsilonRI on human mast cells and basophils and results in inhibition of FcvarepsilonRI-mediated functions. OBJECTIVE: Three modified Fcgamma-Fcvarepsilon (GE) proteins were compared with GE2 for their effect on inhibition of FcvarepsilonRI-mediated cellular responses. METHODS: GE2 was modified to...

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Identifiers

PMID: 17543377
DOI: 10.1016/j.jaci.2007.04.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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