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Structural and Functional Insights Into IgE Receptor Interactions and Disruptive Inhibition

30 Apr 2025

Abstract excerpt

Immunoglobulin E (IgE) plays a critical role in host defense against parasites and venoms but is also best known for its central involvement in allergic reactions. Through interactions with its high- and low-affinity receptors, FcεRI and CD23, respectively, IgE sensitizes mast cells and basophils, drives antigen presentation, regulates antibody production, and overall amplifies type 2 immunity. The unique...

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PMID: 40305523
DOI: 10.1111/imr.70031

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