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Article

Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2007

Gomez Gregorio, Jogie-Brahim Sherryline, Shima Mika, Schwartz Lawrence B

Abstract excerpt

The dramatic effects of the anti-IgE mAb omalizumab to lower free IgE levels and Fc epsilonRI levels on basophils contrast with more modest clinical effects. Accordingly, whether IgE modulates Fc epsilonRI levels and Fc epsilonRI-dependent mediator release in vitro on human skin mast cells (MC(TC...

Read the complete abstract on PubMed

Topics

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Share to Antibodies, Anti-Idiotypic
Share to Antibodies, Monoclonal, Humanized
Share to Cell Degranulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypersensitivity

Share to Immunoglobulin E

Share to Mast Cells

Share to Receptors, IgE

Source

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Identifiers

PMID: 17617628
DOI: 10.4049/jimmunol.179.2.1353
PMCID: PMC2396781

Genes

PGD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17617628-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells.PMID 17617628Read ↗

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