Article
Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.
Journal of the American College of Cardiology - 19 Aug 2008
Sehnert Amy J, Daniels Susan E, Elashoff Michael, Wingrove James A, Burrow Christopher R, Horne Benjamin, Muhlestein Joseph B, Donahue Mark, Liggett Stephen B, Anderson Jeffrey L, Kraus William E
Abstract excerpt
OBJECTIVES: This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF). BACKGROUND: Discordant results exist for genetic associations between adrenergic receptor alleles and end points of beta-blocker response in HF patients. METHODS: We identified 637 patients enrolled in 2 U.S. cardiovascular genetic registries with HF and left ventricular systolic...
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