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Article

Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers.

The pharmacogenomics journal - 1 Feb 2022

Guerra Leonardo A, Lteif Christelle, Arwood Meghan J, McDonough Caitrin W, Dumeny Leanne, Desai Ankit A, Cavallari Larisa H, Duarte Julio D

Abstract excerpt

Single nucleotide polymorphisms (SNPs) have been associated with differential beta-blocker (BB) effects on heart rate, blood pressure, and left ventricular ejection fraction in various patient populations. This study aimed to determine if SNPs previously associated with BB response are also associated with differential survival in heart failure (HF) patients receiving BBs. HF patient data were derived from...

Read the complete abstract on PubMed

Topics

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Share to Adrenergic beta-Antagonists
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Heart Failure

Share to Proportional Hazards Models

Share to Receptors, Adrenergic, beta-1

Share to Receptors, Adrenergic, beta-2

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 34642472
DOI: 10.1038/s41397-021-00257-1
PMCID: PMC8799480

Genes

ADRB1
ADRB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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